Datuk Dr. Senasi's wife Datin Padmani Devi Sharma is an excellent home keeper and had been a mother & teacher in raising their children.

Datuk Dr. Senasi's eldest son, Dr Ramdas Senasi MBBS MRCS FRCR is a Consultant Paediatric Radiologist. Dr Ramdas Senasi's lives with his family in the English countryside and also is involved in the MedTech industry. He speaks extensively around the world and advises and sit on various Medical Technology companies as an advisor and stakeholder. He was instrumental in introducing affordable robotic surgery into Malaysia and is currently involved in several private and public projects in Malaysia.